Selective Antibody Deficiency With Normal Immunoglobulins

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By nclexnursing

Even though people have normal or near-normal quantities of antibodies, selective antibody deficiency with normal immunoglobulins is defined by an insufficient response to specific types of antigens (foreign substances in the body) but not to others (immunoglobulins).

Sinus and lung infections are common in people with selective antibody deficiency and normal immunoglobulins.

Doctors diagnose the condition by looking at immunoglobulin levels in the blood and how well people respond to immunizations.

Treatment involves pneumococcal conjugate vaccine vaccination, medicines to treat infection and prevent infection, and immune globulin in some cases.

A primary immunodeficiency condition is selective antibody deficiency with normal immunoglobulins. It is a prevalent immunodeficiency that leads to frequent sinus and lung infections. Certain immunizations (known as polysaccharide vaccines), such as one type of the pneumococcal vaccine, are ineffective in people with this condition.

Antigens from the bacteria or viruses that vaccines are designed to protect against are found in vaccines. The immune system normally reacts to a vaccine by creating chemicals (such as antibodies) and mobilizing white blood cells that detect and/or kill the bacteria or virus represented in the vaccine. When persons who have been vaccinated are exposed to a certain microbe or virus, their immune systems create antibodies and take other measures to avoid or decrease sickness. Antibodies are not produced in response to polysaccharide vaccinations in people with selective antibody deficiency.

Affected patients suffer from a lot of sinus and lung infections, as well as allergy symptoms like a chronic runny and stuffy nose (rhinitis), a rash, and asthma. The disorder’s severity varies.

Some children have a milder version of the illness that goes away on its own.

Diagnosis Antibody Defeciency

Immunoglobulin levels and vaccination response are measured using blood testing.
Because early healthy children may have many sinus and lung infections and have inadequate reactions to certain immunizations, children are not screened for this disease until beyond the age of two.

Blood tests are used to assess how successfully the body creates immunoglobulins in response to immunizations and to monitor immunoglobulin levels. The diagnosis is confirmed by normal antibody levels and a poor response to some immunizations.


  • Vaccination against pneumococcal conjugate pneumonia
  • Antibiotics to treat infections
  • Sometimes immune globulin

Pneumococcal conjugate vaccine is given to children as part of their standard childhood vaccines to prevent pneumococcal infections. This vaccine, unlike the pneumococcal polysaccharide vaccine, is effective in children with selective antibody deficiency and normal immunoglobulins.

Infections of the sinuses and lungs, as well as allergy symptoms, are treated. When infections reoccur after treatment, people are sometimes given antibiotics (such as amoxicillin and trimethoprim/sulfamethoxazole) to prevent them from happening again.

When illnesses reoccur often despite the use of antibiotics, people are occasionally given immune globulin injections (antibodies obtained from the blood of people with a normal immune system). Immune globulin can be administered intravenously (into a vein) or subcutaneously (under the skin) (subcutaneously).

Complete information about selective antibody deficiencies, including diagnosis, therapy, and guidance for those who are affected.

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Nursing Quiz

An allergic reaction to physical stimulation, such as pressure on the skin or a slight injury, is known as a physical allergy. Symptoms may appear only in response to a physical trigger for some people. Other people’s reactions to other allergies are exacerbated by the physical trigger. What is an example of a physical trigger that isn’t one of the following?

A. Cold

B. Pollen

C. Sunlight

D. Vibration

The Correct Answer is B. Pollen and other plant-derived compounds can produce allergic reactions known as “seasonal allergies,” which occur only at certain periods of the year when the substances that cause them are transported in the air. Physical triggers include options A, C, and D. Heat and other stimuli that promote perspiration are some instances (such as stress or exercise).