Causes of Alzheimer disease an unusual collection of protein fragments is called plaque. These clusters can be discovered between nerve cells in an Alzheimer’s patient’s brain. Damaged nerve cells can also be seen under a microscope. Neurofibrillary tangles, a type of tangle, are present in them. These are made up of twisted protein strands of a different kind.
Plaque and tangles contribute to structural and chemical issues. It appears that Alzheimer’s disease causes brain regions that typically communicate with one another to become disconnected.